G. Leisching

Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human monocyte-derived macrophages and blunt glycolysis in response to antigenic stimuli.

This study examines how chronic exposure to type I interferons affects macrophage metabolism, revealing distinct metabolic profiles and functional changes in response to antigenic stimuli.

Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring

This study shows that chronic IFNα treatment in rats causes hypermetabolic immune cells, increased plasma succinate, and impaired bacterial response.

2′-5′-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion

This study shows that OASL inhibits M. tuberculosis replication and promotes proinflammatory cytokine secretion in THP-1 cells.