Polyamine Metabolism Regulates the T Cell Epigenome Through Hypusination
D. J. Puleston, F. Baixauli, D. E. Sanin, M. Villa, A. Kabat, M. M. Kaminski, H. Weiss, K. Grzes, L. J. Flachsmann, C. S. Field, M. Stanckzak, L. Schimmelpfennig, F. Hassler, C. Wang, N. Yosef, , E. L. Pearce
This study shows that polyamine metabolism, specifically through hypusination, is essential for maintaining T cell subset identity by regulating the epigenome and transcriptional programs.
bioRxiv · Jan 24, 2020 · PreprintImmunology