Author

D. J. Puleston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:statistical model· 2

Frequent Co-Authors

D. E. Sanin· 2 shared E. J. Pearce· 2 shared E. L. Pearce· 2 shared F. Baixauli· 2 shared J. M. Buescher· 2 shared M. Villa· 2 shared A. Hackl· 1 shared A. K. Simon· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersImmunology

D. E. Sanin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment

M. Villa, D. E. Sanin, P. Apostolova, M. Corrado, A. M. Kabat, C. Cristinzio, A. Regina, G. Carrizo, N. Rana, M. A. Stanczak, F. Baixauli, K. M. Grzes, J. Cupovic, F. Solagna, A. Hackl, , E. L. Pearce

This study identifies a PGE2-autophagy-glutathione axis that enables CD8+ T cells to adapt metabolically to the intestinal microenvironment.

bioRxiv · Mar 13, 2023 · PreprintImmunology

Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Y.-T. Wang, A. Trzeciak, W. S. Rojas, P. Saavedra, Y.-T. Chen, R. Chirayil, J. I. Etchegaray, C. D. Lucas, D. J. Puleston, K. R. Keshari, J. S. A. Perry

This study identifies two macrophage states induced by chronic hypoxia that enhance efferocytosis through metabolic and transcriptional adaptations.

bioRxiv · Aug 4, 2022Immunology

Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells

D. Zhou, M. Borsa, D. J. Puleston, S. Zellner, J. Capera, S. Sanderson, L. Jostins, C. Behrends, G. Alsaleh, A. K. Simon

The paper identifies IL-7Rα as a key autophagosomal cargo in proliferating CD4+ T cells using a transgenic mouse model with LC3 proximity labeling.

bioRxiv · Dec 8, 2021 · PreprintImmunology

Polyamine Metabolism Regulates the T Cell Epigenome Through Hypusination

D. J. Puleston, F. Baixauli, D. E. Sanin, M. Villa, A. Kabat, M. M. Kaminski, H. Weiss, K. Grzes, L. J. Flachsmann, C. S. Field, M. Stanckzak, L. Schimmelpfennig, F. Hassler, C. Wang, N. Yosef, , E. L. Pearce

This study shows that polyamine metabolism, specifically through hypusination, is essential for maintaining T cell subset identity by regulating the epigenome and transcriptional programs.

bioRxiv · Jan 24, 2020 · PreprintImmunology