M. Villa

Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment

This study identifies a PGE2-autophagy-glutathione axis that enables CD8+ T cells to adapt metabolically to the intestinal microenvironment.

Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection

The paper shows that Th2 lymphocytes in mesenteric adipose tissue interact with stromal cells to influence adiposity during helminth infection.

Fitness costs and benefits in response to artificial artesunate selection in Plasmodium

This study examines the fitness costs and benefits of artesunate resistance in Plasmodium relictum by comparing selected lines to their ancestral counterparts in both vertebrate and mosquito hosts.

The transmission-blocking effects antimalarial drugs revisited: mosquito fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine

This study evaluates the transmission-blocking effects of artesunate and sulfadoxine-pyrimethamine on malaria parasites in mosquitoes, finding increased oocysts and reduced sporozoites when infected mosquitoes feed on SP-treated blood.

Experimental evolution of virulence and associated traits in a Drosophila melanogaster - Wolbachia symbiosis

The study evolves Drosophila melanogaster infected with Wolbachia wMelPop under high temperature and late reproduction conditions to test if virulence decreases, but finds no reduction in virulence or associated traits.

Polyamine Metabolism Regulates the T Cell Epigenome Through Hypusination

This study shows that polyamine metabolism, specifically through hypusination, is essential for maintaining T cell subset identity by regulating the epigenome and transcriptional programs.

High-throughput isolation and culture of human gut bacteria with droplet microfluidics

The paper develops a droplet microfluidics platform to isolate and culture human gut bacteria, demonstrating its use in studying metabolic variation and growth kinetics.