Requirement of sequential hydrolysis by CD73 and ALP for uptake of vitamin B2 into cells
N. Shichinohe, D. Kobayashi, A. Izumi, K. Hatanaka, R. Fujita, T. Kinoshita, N. Inoue, N. Hamaue, K. Wada, Y. Murakami
The paper shows that CD73 and ALP sequentially hydrolyze FAD to riboflavin, which is then taken up by cells, and this process is impaired in GPI-deficient cells.
bioRxiv · Jul 20, 2022 · PreprintBiochemistry