Author

K. Hegstad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

C. S. Lentz· 2 shared M. Johannessen· 2 shared A. A. Sekh· 1 shared A. Mahmutovic· 1 shared A. Sundsfjord· 1 shared B. Singh· 1 shared C. Ajayi· 1 shared C. Crowe-McAuliffe· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

C. S. Lentz

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Author profile →

3 papers

Recent·Most cited

High-throughput single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities.

J. Hira, B. Singh, T. Halder, A. Mahmutovic, C. Ajayi, A. A. Sekh, K. Hegstad, M. Johannessen, C. S. Lentz

The paper introduces CPPT, a method to profile and trace phenotypic subpopulations in isogenic bacterial communities, revealing clinically relevant biomarkers for antibiotic resistance.

bioRxiv · Nov 2, 2023 · PreprintMicrobiology

Comprehensive Virulence Profiling and Evolutionary Analysis of Specificity Determinants in Staphylococcus aureus Two-Component Systems

S. D. Ahator, K. Wenzl, K. Hegstad, C. S. Lentz, M. Johannessen

This study examines TCSs in S. aureus USA300, identifying virulence regulatory pathways and specificity determinants through mutant analysis and structural modeling.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Structural basis for PoxtA-mediated resistance to Phenicol and Oxazolidinone antibiotics

C. Crowe-McAuliffe, V. Murina, M. Kasari, H. Takada, K. J. Turnbull, Y. S. Polikanov, A. Sundsfjord, K. Hegstad, G. C. Atkinson, D. N. Wilson, V. Hauryliuk

This paper presents cryo-EM structures of PoxtA bound to the ribosome, revealing its mechanism of antibiotic resistance by perturbing tRNA and altering nascent chain conformation.

bioRxiv · Jun 18, 2021Microbiology