Structural and functional studies of the RBPJ-SHARP complex reveal conserved corepressor binding site
Z. Yuan, B. D. VanderWielen, B. D. Giaimo, L. Pan, C. E. Collins, A. Turkiewicz, K. Hein, F. Oswald, T. Borggrefe, R. A. Kovall
This study determines the structure of the RBPJ-SHARP complex and shows that SHARP binding is essential for RBPJ's repressor function in Notch signaling.
bioRxiv · May 10, 2018Biochemistry