Author

T. Borggrefe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

B. D. Giaimo· 4 shared F. Oswald· 3 shared F. Ferrante· 2 shared M. Bartkuhn· 2 shared R. Kovall· 2 shared T. Friedrich· 2 shared Z. Yuan· 2 shared A. Cerwenka· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

B. D. Giaimo

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Author profile →

4 papers

Recent·Most cited

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

D. Huynh, P. Hoffmeister, T. Friedrich, K. Zhang, M. Bartkuhn, F. Ferrante, B. D. Giaimo, R. Kovall, T. Borggrefe, F. Oswald, J. C. M. Gebhardt

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

bioRxiv · Dec 19, 2023Biophysics

The structure, binding, and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3

D. Hall, B. D. Giaimo, S.-S. Park, W. Hemmer, T. Friedrich, F. Ferrante, M. Bartkuhn, Z. Yuan, F. Oswald, T. Borggrefe, J. Rual, R. Kovall

This paper defines the RBPJ-interacting domain of L3MBTL3 and reports the crystal structure of the RBPJ-L3MBTL3-DNA complex, revealing molecular interactions and functional consequences of mutations.

bioRxiv · Feb 9, 2022Biochemistry

Endothelial Rbpj is essential for the education of tumour-associated macrophages

R. Mülfarth, E. Alsina-Sanchis, I. Moll, S. Böhn, L. Wiedmann, L. Jordana Urriza, T. Ziegelbauer, J. Taylor, F. De Angelis Rigotti, A. Stögbauer, B. D. Giaimo, A. Cerwenka, T. Borggrefe, A. Fischer, J. Rodriguez-Vita

This study shows that endothelial Rbpj promotes TAM education in EOC by regulating CXCL2, which drives CD44 expression and cholesterol depletion in TAMs, creating an immunosuppressive TME.

bioRxiv · Dec 20, 2021Cancer Biology

Structural and functional studies of the RBPJ-SHARP complex reveal conserved corepressor binding site

Z. Yuan, B. D. VanderWielen, B. D. Giaimo, L. Pan, C. E. Collins, A. Turkiewicz, K. Hein, F. Oswald, T. Borggrefe, R. A. Kovall

This study determines the structure of the RBPJ-SHARP complex and shows that SHARP binding is essential for RBPJ's repressor function in Notch signaling.

bioRxiv · May 10, 2018Biochemistry