Fighting the spread of antibiotic resistance with bacterial competence inhibitors
A. Domenech, A. R. Brochado, V. Sender, K. Hentrich, B. Henriques-Normark, A. Typas, J.-W. Veening
The paper identifies COM-blockers, which inhibit horizontal gene transfer in S. pneumoniae by disrupting competence without affecting growth or antibiotic activity, offering a strategy to reduce antibiotic resistance spread.
bioRxiv · Jun 27, 2019Microbiology