A. R. Brochado

Pre-trained molecular representations enable antimicrobial discovery

This paper introduces a deep learning framework for antimicrobial discovery that identifies new compounds with antimicrobial potential using pre-trained molecular representations.

Emergence of community behaviors in the gut microbiota upon drug treatment

This study examines how drug treatment affects gut microbiota communities, finding that cross-protection is more common than cross-sensitization, and that metabolic processes contribute to these community behaviors.

The antiphage defense system CBASS controls resistance and enables killing by antifolate antibiotics in Vibrio cholerae

This study shows that the CBASS antiphage defense system in Vibrio cholerae enhances sensitivity to antifolate antibiotics and enables bacterial lysis by these drugs.

High-throughput profiling of drug interactions in Gram-positive bacteria

This study systematically tests drug combinations in Gram-positive bacteria, identifying many new synergies and antagonisms, including effective combinations against drug-resistant strains.

Fighting the spread of antibiotic resistance with bacterial competence inhibitors

The paper identifies COM-blockers, which inhibit horizontal gene transfer in S. pneumoniae by disrupting competence without affecting growth or antibiotic activity, offering a strategy to reduce antibiotic resistance spread.