Interleukin-1 receptor antagonist mediates type I interferon-driven susceptibility to Mycobacterium tuberculosis
Daisy X. Ji, Katherine J. Chen, Naofumi Mukaida, Igor Kramnik, K. Heran Darwin, Russell E. Vance
This study identifies IL-1Ra as a mediator of type I IFN-driven susceptibility to Mtb in a mouse model, showing that reducing IL-1Ra levels protects against infection.
bioRxiv · Aug 10, 2018 · PreprintImmunology