Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases
I. Zivkovic, K. Ivkovic, N. Cvetesic, I. Gruic-Sovulj
The paper shows that the editing domain of class I AARSs preferentially hydrolyzes misaminoacyl-tRNAs to prevent errors, revealing a mechanism of negative catalysis that safeguards cognate tRNAs.
bioRxiv · Oct 18, 2021Biochemistry