The role of the first transmembrane helix in bacterial YidC: Insights from the crystal structure and molecular dynamics simulations
K. J. Nass, I. M. Ilie, M. J. Saller, A. J. M. Driessen, A. Caflisch, R. A. Kammerer, X. Li
This study reports the crystal structure of TmYidC and uses MD simulations to show how the TM1 helix enables YidC to switch between insertase and chaperone conformations.
bioRxiv · Jul 15, 2021Biophysics