Author

A. J. M. Driessen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:fungi (other)· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

N. A. W. de Kok· 2 shared A. Caflisch· 1 shared A. Melcrova· 1 shared B. Peng· 1 shared I. M. Ilie· 1 shared J. Melcr· 1 shared J. S. M. Svendsen· 1 shared J. van der Eyden· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

N. A. W. de Kok

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Heterologous naringenin production in the filamentous fungus Penicillium rubens

B. Peng, L. Dai, R. Iacovelli, A. J. M. Driessen, K. Haslinger

This study produces naringenin in Penicillium rubens using genetic engineering and identifies a novel degradation pathway for this compound.

bioRxiv · Sep 18, 2023 · PreprintBiochemistry

Lateral membrane organization as target of an antimicrobial peptidomimetic compound

A. Melcrova, S. Maity, J. Melcr, N. A. W. de Kok, M. Gabler, J. van der Eyden, W. Stensen, J. S. M. Svendsen, A. J. M. Driessen, S.-J. Marrink, W. H. Roos

This study identifies how the antimicrobial peptide AMC-109 disrupts Staphylococcus aureus membrane organization, leading to loss of methicillin resistance.

Nature Communications · Jul 7, 2023Peer-reviewedBiophysics

The role of the first transmembrane helix in bacterial YidC: Insights from the crystal structure and molecular dynamics simulations

K. J. Nass, I. M. Ilie, M. J. Saller, A. J. M. Driessen, A. Caflisch, R. A. Kammerer, X. Li

This study reports the crystal structure of TmYidC and uses MD simulations to show how the TM1 helix enables YidC to switch between insertase and chaperone conformations.

bioRxiv · Jul 15, 2021Biophysics

CRISPR-Based Transcriptional Activation Tool for Silent Genes in Filamentous Fungi

L. Mozsik, M. Hoekzema, N. A. W. de Kok, R. A. L. Bovenberg, Y. Nygard, A. J. M. Driessen

This paper introduces a CRISPRa tool for activating silent gene clusters in filamentous fungi, demonstrating its ability to produce antimicrobial compounds.

bioRxiv · Oct 13, 2020Microbiology