Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex
X. Zou, S. K. Shanmugam, S. A. Kanner, K. J. Sampson, R. S. Kass, H. M. Colecraft
This study uses targeted protein phosphorylation to show that PKA recruitment to different sites on the KCNQ1/E1 channel complex leads to divergent regulation of IKs, with implications for drug development.
bioRxiv · Sep 12, 2022Physiology