Author

H. M. Colecraft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:electrophysiology· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Kochiss· 1 shared A. M. Rajadhyaksha· 1 shared B. J. Gonzalez· 1 shared C. A. LeDuc· 1 shared C. N. Goulbourne· 1 shared D. Egli· 1 shared D. J. Williams· 1 shared D. Scala Chavez· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

A. Kochiss

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Genetically Encoded Actuator Selectively Boosts L-type Calcium Channels in Diverse Physiological Settings

P. J. del Rivero Morfin, D. Scala Chavez, S. Jayaraman, L. Yang, A. Kochiss, H. M. Colecraft, X. S. Liu, S. O. Marx, A. M. Rajadhyaksha, M. Ben-Johny

This paper develops GeeC, a genetically encoded actuator that boosts L-type CaV1.2/1.3 channel function in cardiomyocytes and neurons, enhancing calcium influx and excitation-transcription coupling.

bioRxiv · Sep 22, 2023 · PreprintPhysiology

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

X. Zou, S. K. Shanmugam, S. A. Kanner, K. J. Sampson, R. S. Kass, H. M. Colecraft

This study uses targeted protein phosphorylation to show that PKA recruitment to different sites on the KCNQ1/E1 channel complex leads to divergent regulation of IKs, with implications for drug development.

bioRxiv · Sep 12, 2022Physiology

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

B. J. Gonzalez, H. Zhao, J. Niu, D. J. Williams, J. Lee, C. N. Goulbourne, Y. Xing, Y. Wang, J. Oberholzer, X. Chen, C. A. LeDuc, W. K. Chung, H. M. Colecraft, J. Gromada, Y. Shen, , D. Egli

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

bioRxiv · Jan 26, 2021Cell Biology