Rapid discovery of drug target engagement by isothermal shift assay
K. J. Webb, K. A. Ball, S. J. Coleman, J. Jacobsen, M. Stowell, W. M. Old
The paper introduces iTSA, an isothermal shift assay for rapid drug target identification, showing higher throughput and multiplexing compared to thermal proteome profiling.
bioRxiv · Apr 5, 2019 · PreprintPharmacology & Toxicology