Author

W. M. Old

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. B. Morgenthaler· 1 shared C. C. Ebmeier· 1 shared C. M. Walsh· 1 shared D. J. Snyder· 1 shared J. Jacobsen· 1 shared K. A. Ball· 1 shared K. J. Webb· 1 shared M. Stowell· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperEvolutionary Biology

A. B. Morgenthaler

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Author profile →

2 papers

Recent·Most cited

Mutations that improve the efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

A. B. Morgenthaler, W. R. Kinney, C. C. Ebmeier, C. M. Walsh, D. J. Snyder, V. S. Cooper, W. M. Old, S. D. Copley

The paper shows that mutations improving a weak-link enzyme's efficiency are rare compared to other adaptive mutations in the genome during bacterial evolution.

bioRxiv · Apr 30, 2019Evolutionary Biology

Rapid discovery of drug target engagement by isothermal shift assay

K. J. Webb, K. A. Ball, S. J. Coleman, J. Jacobsen, M. Stowell, W. M. Old

The paper introduces iTSA, an isothermal shift assay for rapid drug target identification, showing higher throughput and multiplexing compared to thermal proteome profiling.

bioRxiv · Apr 5, 2019 · PreprintPharmacology & Toxicology