Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy
J. Qin, J. Zhang, L. Lin, O. Haji-Ghassemi, Z. Lin, K. J. Woycechowsky, F. van Petegem, Y. Zhang, Z. Yuchi
This study reveals how PLN mutations reduce phosphorylation by altering conformation and PKA interactions, contributing to DCM.
bioRxiv · Nov 16, 2021Biochemistry