BiochemistrybioRxiv
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes
K. K. Mahalingan, E. K. Keenan, M. Strickland…·A. Roll-Mecak
This study identifies active-site residues in TTLL enzymes that determine their specificity for initiating or elongating polyglutamate chains on tubulin, revealing structural basis for their functional specialization.
DOI 10.1038/s41594-020-0462-0