Discordant effects of ex-vivo JAK inhibition on inflammatory responses in colonic compared to ileal mucosa
K. Kaboub, H. Abu-Taha, J. Arrouasse, E. Shaham-Barda, N. Wasserberg, L. Hayman-Manzur, A. Friedenberg, A. Levy-Barda, I. Goren, H. Yanai, Z. Levi, H. Banai-Eran, I. Avni-Biron, J. E. Ollech, S. Cohen-Kedar, , K. M. Rabinowitz
This study examines how JAK inhibition affects inflammatory responses differently in colonic versus ileal mucosa from IBD patients and controls, finding site-specific effects and gene expression changes.
bioRxiv · Jan 18, 2024 · PreprintImmunology