S. Schwartz

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2

This study investigates how secondary structure influences ADAR1 and ADAR2 substrate specificity through synthetic sequence analysis and structural disruption experiments.

Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis

This study shows human intestinal epithelial cells internalize fungal particles via LC3-associated phagocytosis, contributing to mucosal tolerance.

Tm-22 resistance targets a conserved cysteine essential for tobacco mosaic virus (TMV) movement

This study identifies a conserved cysteine in tobamovirus movement proteins that is essential for viral movement and triggers Tm-22 resistance.

Antisense pairing and SNORD13 structure guide RNA cytidine acetylation

This study identifies molecular mechanisms of RNA cytidine acetylation by SNORD13 and NAT10 using mutational analysis and ac4C sequencing in human cells.

Evaluation of Cognitive Function in the Dog Aging Project: Associations with Baseline Canine Characteristics

This study evaluates cognitive function in aging dogs using a large cohort, finding age, activity level, and health history are associated with canine cognitive dysfunction.

High transgene expression is associated with systemic GFP silencing in Nicotiana benthamiana

This study shows that high transgene expression in Nicotiana benthamiana enables systemic gene silencing, while a partial transposase sequence does not affect this process.

B Cell Division Capacity in Germinal Centers Depends on Myc Transcript Stabilization Through m6A mRNA Methylation and IGF2BP3 Functions

The paper shows that m6A methylation via METTL3 stabilizes Myc transcripts in germinal center B cells, which is essential for maintaining GC responses and MYC-driven lymphoma.

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

This study identifies subtype and relapse-specific long non-coding RNAs in B cell precursor acute lymphoblastic leukemia and links them to molecular pathways and epigenetic regulation.