Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity
T. Yotsumoto, N. Morozumi, R. Nakamura, J. Toshimasa, M. Furuya, Y. Abe, T. Nishimura, H. Maeda, H. Ogasawara, Y. Minamitake, K. Kangawa
This study assesses the safety of ASB20123, a C-type natriuretic peptide derivative, showing bone- and cartilage-specific toxicity linked to growth acceleration and identifying epiphyseal plate thickness and BMD as biomarkers.
bioRxiv · May 30, 2019Pharmacology & Toxicology