H. Ogasawara

Measuring integrin force loading rates using a two-step DNA tension sensor

This paper develops a DNA tension sensor to measure integrin force loading rates in live cells, revealing exponential decay in bond lifetime and localized high-force events at cell-substrate junctions.

Unbreakable DNA tension probes show that cell adhesion receptors detect the molecular force-extension curve of their ligands

The paper demonstrates that integrin receptors detect the molecular force-extension curve of their ligands, not just the magnitude of force.

Self-labeling of proteins with chemical fluorescent dyes in BY-2 cells and Arabidopsis seedlings

The paper demonstrates effective self-labeling of proteins in plants using synthetic dyes for studying cell biological processes like endocytosis and microtubule dynamics.

Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity

This study assesses the safety of ASB20123, a C-type natriuretic peptide derivative, showing bone- and cartilage-specific toxicity linked to growth acceleration and identifying epiphyseal plate thickness and BMD as biomarkers.