A persistent invasive phenotype in post-hypoxic tumor cells is revealed by novel fate-mapping and computational modeling
H. L. Rocha, I. Godet, F. Kurtoglu, J. Metzcar, K. Konstantinopoulos, S. Bhoyar, D. M. Gilkes, P. Macklin
The paper uses fate-mapping and computational modeling to show that post-hypoxic tumor cells develop an invasive phenotype that promotes tumor expansion into oxygenated regions.
bioRxiv · Dec 30, 2020Cancer Biology