Biomaterial encapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis
J. M. McKinney, K. A. Pucha, T. N. Doan, L. Wang, L. D. Weinstock, B. T. Tignor, K. L. Fowle, R. D. Levit, L. B. Wood, N. J. Willett
This study shows that encapsulating human mesenchymal stromal cells in alginate microcapsules modulates their paracrine signaling and improves therapeutic outcomes in established osteoarthritis.
bioRxiv · Jul 30, 2020 · PreprintBioengineering