L. B. Wood

Biomaterial encapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis

This study shows that encapsulating human mesenchymal stromal cells in alginate microcapsules modulates their paracrine signaling and improves therapeutic outcomes in established osteoarthritis.

Effects of osteogenic ambulatory mechanical stimulation on early stages of BMP-2mediated bone repair

This study investigates how mechanical loading affects early bone repair stages in a rat model, showing changes in cytokine expression, angiogenesis, and endochondral ossification.

Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.

Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors

This study develops an in vitro muscle parabiosis system to identify rejuvenating factors in aged muscle stem cells by mimicking systemic and local signals.

Mechanical Regulation of Microvascular Angiogenesis

This study investigates how mechanical strain on the extracellular matrix affects microvascular angiogenesis, finding that timing and magnitude of compression significantly influence vessel growth and signaling pathways.

Development of Systemic Immune Dysregulation in a Rat Trauma Model with Biomaterial-Associated Infection

This study investigates the systemic immune response to orthopedic biomaterial-associated infection in rats, finding long-term immune dysregulation and altered cytokine responses.

Experimental control of macrophage pro-inflammatory dynamics using predictive models

This study develops a model-predictive control framework to temporally regulate macrophage polarization using exogenous stimuli, demonstrating the ability to sustain iNOS expression through time-varying input trajectories.