N. J. Willett

Local FK506 delivery induces osteogenesis in in vivo rat bone defect and rabbit spine fusion models

This study shows FK506 induces bone formation in human cells and two in vivo models, and can be used alone or with BMP-2 for spine disorders.

Harnessing Bilayer Biomaterial Delivery of FTY720 as an Immunotherapy to Accelerate Oral Wound Healing

Bilayer FTY720-nanofiber scaffolds promote complete oral wound closure in a mouse model by modulating pro-regenerative immune and stromal cells.

Identifying dysregulated immune cell subsets following critical volumetric muscle loss with pseudo-time trajectories

The paper uses pseudo-time analysis to identify immune cell subset dysregulation in critical versus subcritical volumetric muscle loss in mice.

Multichromatic Near-Infrared Imaging to Assess Interstitial Lymphatic and Venous Uptake In Vivo

This study uses multichromatic near-infrared imaging with tracers to assess in vivo lymphatic and venous fluid clearance in different tissues and under exercise conditions.

Effect of human synovial fluid from osteoarthritis patients and healthy individuals on lymphatic contractility

This study investigates how synovial fluid from osteoarthritis patients and healthy individuals affects lymphatic contractility and cell migration, finding differences in contractile responses and migration rates.

Biomaterial encapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis

This study shows that encapsulating human mesenchymal stromal cells in alginate microcapsules modulates their paracrine signaling and improves therapeutic outcomes in established osteoarthritis.

Effects of osteogenic ambulatory mechanical stimulation on early stages of BMP-2mediated bone repair

This study investigates how mechanical loading affects early bone repair stages in a rat model, showing changes in cytokine expression, angiogenesis, and endochondral ossification.

Mechanical Regulation of Microvascular Angiogenesis

This study investigates how mechanical strain on the extracellular matrix affects microvascular angiogenesis, finding that timing and magnitude of compression significantly influence vessel growth and signaling pathways.

Characterization of OA development between sexes in the rat medial meniscal transection model

This study shows that sex affects OA progression in a rat MMT model, with both sexes showing cartilage degradation and subchondral bone changes.

Effects of BMP-2 dose and delivery of microvascular fragments on healing of bone defects with concomitant volumetric muscle loss

This study tests the effect of BMP-2 dose and co-delivery of microvascular fragments on healing of bone defects with muscle loss, finding dose-dependent bone regeneration without heterotopic ossification.