An allosteric agonist activates BK channels by perturbing coupling between Ca2+ binding and pore opening
G. Zhang, X. Xu, Z. Jia, Y. Geng, H. Liang, J. Shi, M. Marras, C. Abella, K. L. Magleby, J. R. Silva, J. Chen, X. Zou, J. Cui
The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.
bioRxiv · Jan 28, 2022 · PreprintBiophysics