Epistasis between promoter activity and coding mutations shapes gene evolvability
A. F. C. Caballero, I. Gagnon-Arsenault, A. K. Dube, P. C. Despres, P. Kumar, K. Lafontaine, J. N. Pelletier, C. R. Landry
The paper shows that expression level masks the effects of coding mutations, demonstrating that expression level dictates their fitness impact.
bioRxiv · Jun 7, 2022Evolutionary Biology