Impact of combinatorial histone modifications on acetyllysine recognition by the ATAD2 and ATAD2B bromodomains
M. Phillips, K. L. Malone, B. W. Boyle, C. Montgomery, I. A. Kressy, F. M. Joseph, K. M. Bright, S. P. Boyson, S. Chang, J. C. Nix, N. L. Young, V. Jeffers, S. E. Frietze, K. C. Glass
This study investigates how ATAD2 and ATAD2B bromodomains recognize acetylated lysine on histones in the presence of other modifications, revealing distinct binding modes and mechanisms.
bioRxiv · Nov 14, 2022Biochemistry