Author

N. L. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Assay:ChIP-seq· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

K. F. Poncha· 3 shared B. D. Strahl· 2 shared F. M. Joseph· 2 shared G. C. Fox· 2 shared K. Jain· 2 shared A. Jazayeri· 1 shared A. Vaidya· 1 shared B. C. Taylor· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

K. F. Poncha

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

G. C. Fox, K. F. Poncha, B. R. Smith, L. N. van der Maas, N. N. Robbins, B. Graham, J. M. Dowen, B. D. Strahl, N. L. Young, K. Jain

The paper shows that H3K18 and H3K23 acetylation enhance MLL1-mediated H3K4 methylation, while other modifications are less affected by tail acetylation.

bioRxiv · May 13, 2024 · PreprintBiochemistry

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

Y. Xiong, J. Sharma, M. N. Young, W. Xiong, A. Jazayeri, K. F. Poncha, M. X. Ilagan, Q. Wang, H. Zheng, N. L. Young, M. Sardiello

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

bioRxiv · Oct 16, 2023Cell Biology

Impact of combinatorial histone modifications on acetyllysine recognition by the ATAD2 and ATAD2B bromodomains

M. Phillips, K. L. Malone, B. W. Boyle, C. Montgomery, I. A. Kressy, F. M. Joseph, K. M. Bright, S. P. Boyson, S. Chang, J. C. Nix, N. L. Young, V. Jeffers, S. E. Frietze, K. C. Glass

This study investigates how ATAD2 and ATAD2B bromodomains recognize acetylated lysine on histones in the presence of other modifications, revealing distinct binding modes and mechanisms.

bioRxiv · Nov 14, 2022Biochemistry

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

K. Jain, M. R. Marunde, J. M. Burg, S. L. Gloor, F. M. Joseph, K. F. Poncha, Z. B. Gillespie, K. L. Rodriguez, I. K. Popova, N. W. Hall, A. Vaidya, S. A. Howard, H. F. Taylor, L. Mukhsinova, U. C. Onuoha, , B. D. Strahl

The paper shows that H3 tail acetylation enhances accessibility of both H3K4 methyl readers and writers, revealing an acetylation-mediated chromatin switch that modulates H3K4 methylation read-write capability.

bioRxiv · Feb 28, 2022Biochemistry