Author

J. C. Nix

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. C. Glass· 3 shared K. L. Malone· 3 shared M. Phillips· 3 shared A.-L. Steckelberg· 2 shared D. A. Costantino· 2 shared J. S. Kieft· 2 shared M. Tonelli· 2 shared R. C. Page· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

K. C. Glass

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP

M. D. Callahan, M. Hodul, E. C. Carroll, M. Ravalin, C. M. Nadel, A. R. de Silva, A. R. Cupo, L. E. McDermott, J. C. Nix, R. C. Page, A. W. Kao, J. E. Gestwicki

This study identifies CHIC2 as a chaperone-independent regulator of CHIP, showing it attenuates CHIP's ubiquitin ligase activity and contributes to neurodegeneration in C. elegans.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Impact of combinatorial histone modifications on acetyllysine recognition by the ATAD2 and ATAD2B bromodomains

M. Phillips, K. L. Malone, B. W. Boyle, C. Montgomery, I. A. Kressy, F. M. Joseph, K. M. Bright, S. P. Boyson, S. Chang, J. C. Nix, N. L. Young, V. Jeffers, S. E. Frietze, K. C. Glass

This study investigates how ATAD2 and ATAD2B bromodomains recognize acetylated lysine on histones in the presence of other modifications, revealing distinct binding modes and mechanisms.

bioRxiv · Nov 14, 2022Biochemistry

Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

A. K. Singh, M. Phillips, S. Alkrimi, M. Tonelli, S. P. Boyson, K. L. Malone, J. C. Nix, K. C. Glass

This study investigates the binding specificity of PfBDP1 bromodomain to acetylated histones in P. falciparum, revealing its preference for tetra-acetylated H4 and potential therapeutic implications.

bioRxiv · Aug 2, 2022Biophysics

Coordination of di-acetylated histone ligands by the ATAD2 bromodomain

C. M. Evans, M. Phillips, K. L. Malone, M. Tonelli, G. Cornilescu, C. Cornilescu, S. Holton, M. Gorjanacz, L. Wang, S. Carlson, J. C. Gay, J. C. Nix, B. Demeler, J. L. Markley, K. C. Glass

This study identifies how the ATAD2 bromodomain recognizes di-acetylated histone tails through residue-specific interactions and confirms its monomeric state using biophysical techniques.

bioRxiv · Jul 23, 2021Biochemistry

Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

T. N. Starr, N. Czudnochowski, F. Zatta, Y.-J. Park, Z. Liu, A. Addetia, D. Pinto, M. Beltramello, P. Hernandez, A. J. Greaney, R. Marzi, W. G. Glass, I. Zhang, A. S. Dingens, J. E. Bowen, , Veesler

This study identifies antibodies against SARS-CoV-2 that balance neutralization potency and breadth, with some showing high resistance to viral escape.

bioRxiv · Apr 6, 2021 · PreprintMicrobiology

The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

A.-L. Steckelberg, Q. Vicens, D. A. Costantino, J. C. Nix, J. S. Kieft

The paper presents the crystal structure of a polerovirus xrRNA, revealing sequence diversity within a conserved fold and explaining conservation patterns and new interactions.

bioRxiv · Apr 30, 2020Biochemistry

A non-canonical metal center drives activity of the Sediminispirochaeta smaragdinae metallo-β- lactamase SPS-1

Z. Cheng, J. VanPelt, A. Bergstrom, C. Bethel, A. Katko, C. Miller, K. Mason, E. Cumming, H. Zhang, R. Kimble, S. Fullington, S. L. Bretz, J. C. Nix, R. A. Bonomo, D. L. Tierney, , M. W. Crowder

This study characterizes the metallo-β-lactamase SPS-1 from Sediminispirochaeta smaragdinae, revealing a novel metal binding site that challenges inhibitor design.

bioRxiv · Jun 2, 2018Biochemistry

A folded viral noncoding RNA blocks host cell exoribonucleases through programmed remodeling of RNA structure

A.-L. Steckelberg, B. M. Akiyama, D. A. Costantino, T. L. Sit, J. C. Nix, J. S. Kieft

The paper identifies a novel RNA structure-dependent mechanism in dianthoviruses that blocks exoribonucleases, revealing convergent evolution of xrRNAs across unrelated viral families.

bioRxiv · Feb 9, 2018Biochemistry