Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
Y.-Y. Ding, H. Kim, K. Madden, J. P. Loftus, G. M. Chen, D. H. Allen, R. Zhang, J. Xu, Y. Hu, S. K. Tasian, K. Tan
The paper identifies synergistic genetic targets in Ph-like B-ALL using network analysis to guide combination therapy, showing improved efficacy in preclinical models.
bioRxiv · Jan 6, 2021Cancer Biology