Author

G. M. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:CITE-seq· 2 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. L. Levine· 2 shared E. J. Wherry· 2 shared F. D. Bushman· 2 shared J. A. Fraietta· 2 shared J. J. Melenhorst· 2 shared K. Tan· 2 shared N. V. Frey· 2 shared R. M. Young· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

B. L. Levine

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

A. J. Dimitri, A. E. Baxter, G. M. Chen, C. R. Hopkins, G. T. Rouin, H. Huang, W. Kong, C. H. Holliday, V. Wiebking, R. Bartoszek, S. Drury, K. Dalton, O. M. Koucky, Z. Chen, J. R. Giles, , J. A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

bioRxiv · Mar 29, 2024Immunology

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

J. J. Melenhorst, G. M. Chen, M. Wang, D. . L. Porter, P. Gao, S. Bandyopadhyay, I. Pruteanu-Malinici, C. L. Nobles, S. Maji, N. V. Frey, S. I. Gill, L. Tian, I. Kulikovskaya, M. Gupta, M. M. Davis, , C. H. June

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

bioRxiv · May 7, 2021 · PreprintImmunology

Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Y.-Y. Ding, H. Kim, K. Madden, J. P. Loftus, G. M. Chen, D. H. Allen, R. Zhang, J. Xu, Y. Hu, S. K. Tasian, K. Tan

The paper identifies synergistic genetic targets in Ph-like B-ALL using network analysis to guide combination therapy, showing improved efficacy in preclinical models.

bioRxiv · Jan 6, 2021Cancer Biology

Consensus on Molecular Subtypes of Ovarian Cancer

G. M. Chen, L. Kannan, L. Geistlinger, V. Kofia, Z. Safikhani, D. M. A. Gendoo, G. Parmigiani, M. Birrer, B. Haibe-Kains, L. Waldron

The paper evaluates three ovarian cancer subtype classifiers, finds they are not robust, and proposes a consensus classifier with a 100-gene signature that improves stratification of a minority of tumors.

bioRxiv · Jul 12, 2017Cancer Biology