Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
D. Pla-Martin, A. Sen, S. Kallabis, J. Nuechel, K. Maliphol, J. Hofmann, M. Krueger, R. J. Wiesner
The paper identifies a mechanism involving Twinkle, ATAD3, SAMM50, and VPS35 that selectively removes mutant mtDNA through autophagy, offering therapeutic potential for mtDNA diseases and aging.
bioRxiv · Aug 6, 2021 · PreprintCell Biology