Author

R. J. Wiesner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Hofmann· 2 shared A. Bozec· 1 shared A. Sen· 1 shared B. Eggers· 1 shared C. Berwanger· 1 shared C. S. Clemen· 1 shared D. Mielenz· 1 shared D. Mougiakakos· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

J. Hofmann

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria

C. Berwanger, D. Terres, D. Pesta, B. Eggers, K. Marcus, I. Wittig, R. J. Wiesner, R. Schroeder, C. S. Clemen

This paper establishes an immortalised murine desminopathy model and finds reduced mitochondrial proton leak and ADP/ATP translocase levels in desminopathy myotubes.

bioRxiv · Nov 10, 2023Cell Biology

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

D. Pla-Martin, A. Sen, S. Kallabis, J. Nuechel, K. Maliphol, J. Hofmann, M. Krueger, R. J. Wiesner

The paper identifies a mechanism involving Twinkle, ATAD3, SAMM50, and VPS35 that selectively removes mutant mtDNA through autophagy, offering therapeutic potential for mtDNA diseases and aging.

bioRxiv · Aug 6, 2021 · PreprintCell Biology

Mitochondrial function is essential for humoral immunity by controlling flux of the TCA cycle, phosphatidic acid and mTOR activity in B cells

S. Urbanczyk, O. Baris, J. Hofmann, F. Golombek, K. Castiglione, X. Meng, A. Bozec, D. Mougiakakos, S. R. Schulz, W. Schuh, U. Schloetzer-Schrehardt, T. Steinmetz, S. Brodesser, R. J. Wiesner, D. Mielenz

This study shows that mitochondrial function is critical for B cell differentiation into plasma cells by regulating TCA cycle flux, phosphatidic acid levels, and mTOR activity.

bioRxiv · Jan 14, 2021 · PreprintImmunology