J. Hofmann

B/T cell crosstalk and aberrant inflammatory IgG exacerbate autoimmune intestinal inflammation

This study identifies B cell-driven inflammatory mechanisms, including aberrant IgG production and CD86-mediated T cell activation, as contributors to exacerbated intestinal inflammation in IBD.

Alcohol-sourced acetate impairs T cell function by promoting cortactin acetylation

This study shows alcohol-sourced acetate impairs T cell function by promoting cortactin acetylation, which disrupts actin binding and reduces migration and immune responses.

Assessment of binocular fixational eye movements including cyclotorsion with split-field binocular scanning laser ophthalmoscopy

This study uses a split-field binocular scanning laser ophthalmoscope to measure binocular fixational eye movements, revealing strong coupling between microsaccades and cyclotorsion in both eyes.

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

The paper identifies a mechanism involving Twinkle, ATAD3, SAMM50, and VPS35 that selectively removes mutant mtDNA through autophagy, offering therapeutic potential for mtDNA diseases and aging.

High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING

PING enables high-throughput, accurate KIR genotyping by addressing structural complexity and homology challenges in short-read sequencing data.

Mitochondrial function is essential for humoral immunity by controlling flux of the TCA cycle, phosphatidic acid and mTOR activity in B cells

This study shows that mitochondrial function is critical for B cell differentiation into plasma cells by regulating TCA cycle flux, phosphatidic acid levels, and mTOR activity.