DONSON, a gene responsible for microcephalic primordial dwarfism, ensures proper centriole duplication cycle by maintaining centriole engagement during interphase.
K. Matsuhashi, K. Watanabe, K. K. Ito, T. Chinen, S. Hata, G. S. Stewart, D. Kitagawa
This study shows that DONSON regulates centriole duplication by maintaining centriole engagement during interphase, and its loss causes centrosome overduplication and chromosome segregation errors in MPD patient cells.
bioRxiv · May 10, 2020 · PreprintCell Biology