T. Chinen

An antioxidant screen identifies ascorbic acid for prevention of light-induced mitotic prolongation in live cell imaging

This study identifies ascorbic acid as an effective antioxidant to prevent light-induced mitotic defects in live cell imaging of human diploid cells.

Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

The paper identifies lineage-specific therapeutic vulnerabilities in AML subtypes using a two-group comparison approach based on genetic data from the Cancer Dependency Map.

ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid cells

This study compares ssDNA and dsDNA as HDR donors for CRISPR-mediated gene tagging in human diploid cells, finding dsDNA more efficient for precise insertion.

Stress-dependent cell stiffening by tardigrade tolerance proteins through reversible formation of cytoskeleton-like filamentous network and gel-transition

This study identifies CAHS proteins as stress-dependent cytoskeletal-like proteins that form reversible filaments and gels to enhance cell stiffness and dehydration resistance in tardigrades.

A CRISPR-del-based pipeline for complete gene knockout in human diploid cells

This study introduces a CRISPR-del pipeline to achieve complete gene knockout in human diploid cells by inducing large chromosomal deletions, showing higher efficiency than conventional methods.

Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly

This study shows that centrioles and PCM cooperatively recruit CEP192 to spindle poles, promoting bipolar spindle formation in human cells.

DONSON, a gene responsible for microcephalic primordial dwarfism, ensures proper centriole duplication cycle by maintaining centriole engagement during interphase.

This study shows that DONSON regulates centriole duplication by maintaining centriole engagement during interphase, and its loss causes centrosome overduplication and chromosome segregation errors in MPD patient cells.

Cep57 and Cep57L1 cooperatively maintain centriole engagement during interphase to ensure proper centriole duplication cycle

This study shows that Cep57 and Cep57L1 work together to keep centrioles engaged during interphase, preventing premature disengagement and ensuring proper centriole duplication and chromosome segregation.