Author

K. McCrae

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

R. Alluri· 2 shared A. Joehlin-Price· 1 shared C. Braley· 1 shared E. Esakov· 1 shared E. Ruben· 1 shared F. Tedesco· 1 shared G. Dey· 1 shared J. Lathia· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

R. Alluri

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Author profile →

2 papers

Recent·Most cited

LCK Regulates Homologous Recombination DNA Repair Identifying a New Therapeutic Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer

G. Dey, R. Bharti, C. Braley, R. Alluri, E. Esakov, K. Crean-Tate, K. McCrae, A. Joehlin-Price, P. G. Rose, J. Lathia, Z. Gong, O. Reizes

This study identifies LCK's role in HR repair in ovarian cancer, showing its inhibition sensitizes HR-proficient tumors to PARP inhibitors.

bioRxiv · Mar 3, 2021 · PreprintCancer Biology

X-ray and solution structures of human beta-2 glycoprotein I reveal a new mechanism of autoantibody recognition

E. Ruben, W. Planer, M. Chinnaraj, Z. Chen, X. Zuo, V. Pengo, V. De Filippis, R. Alluri, K. McCrae, P. Macor, F. Tedesco, N. Pozzi

This paper reveals the structure of human beta-2 glycoprotein I and shows that its elongated, flexible conformation allows autoantibodies to recognize an epitope without phospholipids.

bioRxiv · Feb 25, 2020Biochemistry