Z. Gong

AggreBots: configuring CiliaBots through guided, modular tissue aggregation

The paper introduces AggreBots, a platform for creating designer motility patterns in multicellular tissues by spatially controlling the aggregation of epithelial spheroids, achieving greater motility than traditional CiliaBots.

Visualizing the M2 muscarinic acetylcholine receptor activation regulated by aromatic ring dynamics

This study uses atomic-level simulations to show how ligand binding modulates conformational dynamics of the M2 muscarinic receptor, revealing key aromatic residue interactions involved in activation.

Deletion of absent in melanoma (AIM) 2 gene alters bone morphology

This study investigates the impact of AIM2 gene deletion on bone morphology in mice, finding increased cortical thickness and decreased trabecular bone volume and BMD in aged AIM2 null females.

The Myc-Like Mlx Network Impacts Aging and Metabolism

This study shows that inactivating the Mlx network in mice accelerates aging-related phenotypes and increases cancer risk, similar to Myc inactivation, but with different lifespan outcomes.

Enhancement of Protein Stability by Quenching Millisecond Conformational Dynamics

This study links millisecond conformational dynamics of ubiquitin to protein stability through alanine mutations affecting the C-terminal retracted state.

Rapid and unbiased enrichment of extracellular vesicles via meticulously engineered peptide

This paper introduces a method to rapidly and efficiently isolate extracellular vesicles with high purity and recovery, enabling downstream analyses for cancer diagnostics.

The Multifaceted Effects of Short-Term Acute Hypoxia Stress: Insights into the tolerance mechanism of Propsilocerus akamusi (Diptera: Chironomidae)

This study investigates how P. akamusi tolerates acute hypoxia through multi-omics analysis, revealing metabolic and enzymatic adaptations that support its survival in eutrophic lakes.

A hierarchical strategy to decipher protein dynamics in vivo with chemical cross-linking mass spectrometry

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide Myc Inactivation

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

Zebrafish embryos are more efficient and robust than zebrafish larvae in evaluating human norovirus infectivity

This study shows zebrafish embryos are more efficient and robust than larvae for evaluating human norovirus infectivity, enabling virus passaging and UV inactivation testing.

Kynurenic acid promotes A1 to A2 astrocyte conversion against HIV-associated neurocognitive disorder

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.

Preferential cross-linking of the stereospecific complex over the encounter complexes by DOPA2, a faster cross-linker than DSS

This study compares DOPA2 and DSS cross-linkers, finding that faster cross-linking favors the stereospecific complex over encounter complexes in transient protein interactions.

A zebrafish embryo screen utilizing gastrulation for identification of anti-metastasis drugs

The paper presents a zebrafish embryo-based screen for anti-metastasis drugs using gastrulation as a model, identifying Adrenosterone and Pizotifen as potential candidates.

PP2A forestalls mitophagy by dephosphorylating Parkin and ubiquitin

This study identifies PP2A as a phosphatase that dephosphorylates Parkin and ubiquitin, thereby inhibiting mitophagy.

Spatially resolved profiling of protein conformation and interactions by biocompatible chemical cross-linking in living cells

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

Chemo-mechanical Diffusion Waves Orchestrate Collective Dynamics of Immune Cell Podosomes

This study develops a chemo-mechanical model to explain how immune cell podosomes generate oscillatory growth and coordinated wave dynamics through actin polymerization, myosin contractility, and actin diffusion.

Nucleobase clustering contributes to the formation and hollowing of repeat-expansion RNA condensate

This study shows that nucleobase clustering in RNA with repeat expansions leads to the formation and hollowing of RNA condensates, contributing to neurodegenerative disease mechanisms.

Autophagy-dependent TOR reactivation drives fungal growth in living host rice cells

This study shows that autophagy-dependent TOR reactivation via α-ketoglutarate sustains fungal biotrophic growth in host rice cells.

Genome-wide association analysis of cotton salt stress response-related sites

This study identifies SNP markers associated with salt tolerance traits in upland cotton through genome-wide association analysis.

Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

A bacterium-like particle vaccine displaying Zika virus prM-E induces systemic immune responses in mice

Preferential interactions of a crowder protein with the specific binding site of a native protein complex

This paper investigates how crowder proteins affect the binding affinity and kinetics of the EIN-HPr protein complex using NMR and atomistic modeling, revealing preferential interactions that destabilize the complex.

Development of a compact alkynyl-enrichable crosslinker for in-depth in-vivo crosslinking analysis

The paper develops a new alkynyl-enrichable crosslinker for in-vivo crosslinking analysis, identifying 6820 non-redundant crosslinks in human cells with a 1% FDR.

Deep-learning on-chip DSLM enabling video-rate volumetric imaging of neural activities in moving biological specimens

This paper develops a deep-learning enhanced on-chip DSLM system for high-speed volumetric imaging of neural activity in moving Drosophila larvae.

Verticillium dahliae effector VDAL protects MYB6 from degradation by interacting with PUB25/26 E3 ligases for enhancing Verticillium wilt resistance in Arabidopsis

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

LCK Regulates Homologous Recombination DNA Repair Identifying a New Therapeutic Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer

This study identifies LCK's role in HR repair in ovarian cancer, showing its inhibition sensitizes HR-proficient tumors to PARP inhibitors.

Fucoidan but not 2'-Fucosyllactose could inhibit human norovirus replication in zebrafish larvae

This study compares fucoidan and 2'-Fucosyllactose in inhibiting human norovirus replication in zebrafish larvae, finding only fucoidan effectively inhibits replication.