TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
W. Qiao, K. H. M. Wong, J. Shen, W. Wang, J. Wu, J. Li, Z. Lin, Z. Chen, J. P. Matinlinna, Y. Zheng, S. Wu, X. Liu, K. P. Lai, Z. Chen, Y. W. Lam, , K. W. K. Yeung
This study shows Mg2+ promotes bone regeneration initially by modulating macrophage activity but later inhibits bone formation through NF-κB activation and reduced hydroxyapatite precipitation.
bioRxiv · Apr 24, 2020Cell Biology