Cardiac Effects of a Novel pH-Insensitive Sodium-Calcium Exchanger Mouse
R. Zhang, X. Wu, B. Kim, C. Xie, D. Gonzalez, R. Norris, N. Chin, L. Li, S. John, K. Philipson, M. Ottolia, J. I. Goldhaber
This study creates a pH-insensitive NCX1 mouse and finds it has reduced growth, accelerated cardiac repolarization, and is resistant to ischemia/reperfusion injury.
bioRxiv · May 11, 2023 · PreprintBiophysics