The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor
D. Legge, L. Ling, W. Moriarty, D. Lee, M. Szemes, A. Zahed, L. Panousopoulus, W. Y. Chung, Y. Aghabi, J. Barratt, R. Williams, K. Pritchard-Jones, K. Malik, S. Oltean, K. W. Brown
This study identifies ESRP2 as an epigenetically repressed tumour suppressor in Wilms tumour through DNA hypermethylation, showing its ability to inhibit proliferation and suppress tumour growth.
bioRxiv · Nov 2, 2020Cancer Biology