R. Williams

Recombinant manufacturing of multispecies biolubricants

This study develops recombinant lubricin analogs with improved biocompatibility and lubricating properties, demonstrating their tissue binding and joint retention in rats.

Decoding scalp health and microbiome dysbiosis in dandruff

The paper investigates the scalp microbiome in healthy individuals and those with dandruff, identifying propionic acid's role in microbiome balance and its implications for scalp health.

A multistate capture-recapture model to estimate reproduction of North Atlantic right whales

This paper develops a multistate capture-recapture model to estimate calving probabilities in North Atlantic right whales using sightings data from 1990-2019, finding decreased calving rates after a 2010 regime shift and links to prey availability and severe injury.

The extracellular heparan sulfatase SULF2 limits myeloid IFNbeta signaling and Th17 responses in inflammatory arthritis.

This study shows that SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis by modulating heparan sulfate remodeling.

Reliability of dynamic causal modelling of resting state magnetoencephalography

This study evaluates the reliability of dynamic causal modelling of resting-state MEG data using conductance-based models, showing high predictive validity and consistency across sessions.

A multistate capture-recapture model to estimate cause-specific injury and mortality of North Atlantic right whales

This study estimates cause-specific injury and mortality rates of North Atlantic right whales using a multistate capture-recapture model, finding increased entanglement injuries and mortality in females with calves.

Pathogenic entero- and salivatypes harbour changes in microbiome virulence and antimicrobial resistance genes with increasing chronic liver disease severity

The paper identifies changes in oral and gut microbiome virulence and antimicrobial resistance genes associated with increasing severity of chronic liver disease.

Optical nanosensor passivation enables highly sensitive detection of the inflammatory cytokine IL-6

The paper develops a passivated optical nanosensor for IL-6 detection, achieving high sensitivity and specificity in human serum.

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

ROCK2 Knockout Improves Proliferation Rate in a Cellular Model of Down Syndrome

ROCK2 knockout improves cell proliferation in a trisomy 21 cellular model of Down Syndrome, with no effect in euploid cells.

Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

This study shows that incorporating within-host genetic diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks.

Considering decoupled phenotypic diversification between ontogenetic phases in macroevolution: An example using Triggerfishes (Balistidae)

The paper examines ontogenetic variation in locomotor morphology of triggerfishes, revealing decoupled diversification dynamics between adult and juvenile stages.

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors.

This study profiles the effects of the SRC inhibitor AZD0424 in combination with MEK inhibitors, showing reduced compensatory activation and enhanced anti-tumor effects in colorectal cancer models.

Elucidation of SARS-CoV-2 budding mechanisms through molecular dynamics simulations of M and E protein complexes

The paper uses molecular dynamics simulations to study SARS-CoV-2 M and E protein interactions during budding, revealing their roles in membrane curvature and planarity.

Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

This study uses FRET imaging in C. elegans to show stretch-induced conformational changes in twitchin kinase during muscle activity.

Global warming readiness: Feasibility of enhanced biological phosphorus removal from wastewater at 35oC

This study demonstrates that enhanced biological phosphorus removal (EBPR) can be stable at 35°C in lab-scale reactors, with nearly complete phosphorus removal and diverse PAO communities.

The combined treatment of Molnupiravir and Favipiravir results in a marked potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

This study shows that combining Molnupiravir and Favipiravir significantly enhances antiviral efficacy against SARS-CoV-2 in hamsters, reducing viral titers by 4.5 log10 and eliminating detectable virus in 60% of treated animals.

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

This study identifies ESRP2 as an epigenetically repressed tumour suppressor in Wilms tumour through DNA hypermethylation, showing its ability to inhibit proliferation and suppress tumour growth.

Integrative systems approach reveals dynamics of microbiome-metal-ion axis in mesocosms representing tropical urban freshwater canal ecosystem

The paper develops a systems framework to study interactions between macro-organisms, sedimentary microbes, and geochemistry in tropical urban canals after rainfall disturbances.

The isolate Caproiciproducens sp. 7D4C2 produces n-caproate at mildly acidic conditions from hexoses: genome and rBOX comparison with related strains and chain-elongating bacteria

This study isolates and characterizes Caproiciproducens sp. 7D4C2, showing it produces n-caproate at mildly acidic pH from hexoses and compares its genome and rBOX genes to related strains.

Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation

This paper develops a novel allograft model of high-risk prostate cancer that mimics human disease features and responds to radiotherapy.

In vitro biosynthesis of poly-β-1,4-glucan derivatives using a promiscuous glycosyltransferase

This study uses a promiscuous glycosyltransferase to synthesize cello-oligosaccharides and their derivatives, enabling tailored glycan structures for biotechnological applications.

The Power of Citizen Science to Quantify Ecological Risks in Cities

This study uses citizen science data to quantify ecological risks in urban areas by analyzing predation and parasitism in Southern Alligator Lizards across urbanization gradients.

A Systematic Review of the Biomechanical Effects of Harness and Head-Collar use in Dogs

This paper reviews biomechanical effects of harness and head-collar use in dogs, finding that certain harness types reduce shoulder extension in gait, but no studies on head-collars.

Differential effects of emerging broad-spectrum streetlight technologies on landscape-scale bat activity

This study analyzes the impact of different streetlight technologies on bat activity across Jersey, finding negative effects of LED and HPS lights but not MH lights, while highlighting urbanization and road type as larger factors.

The intrinsic predictability of ecological time series and its potential to guide forecasting

The paper quantifies intrinsic predictability of ecological time series using permutation entropy and shows its relationship with model forecasting error.