Author

D. Legge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

K. Malik· 2 shared M. Szemes· 2 shared A. Greenhough· 1 shared A. Moukachar· 1 shared A. Paterson· 1 shared A. Zahed· 1 shared D. Lee· 1 shared E. E. Vincent· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

K. Malik

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2 papers

Recent·Most cited

Glutamine addiction is targetable via altering splicing of nutrient sensors and epitranscriptome regulators

J. Bojko, M. Kollareddy, M. Szemes, J. Bellamy, E. Poon, A. Moukachar, D. Legge, E. E. Vincent, N. Jones, S. Malik, A. Greenhough, A. Paterson, J. H. Park, K. Gallacher, L. Chesler, K. Malik

This study shows PRMT5 inhibition targets MNA neuroblastoma by altering splicing of nutrient sensors and epitranscriptome regulators, leading to growth inhibition and apoptosis.

bioRxiv · Feb 28, 2024 · PreprintCancer Biology

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

D. Legge, L. Ling, W. Moriarty, D. Lee, M. Szemes, A. Zahed, L. Panousopoulus, W. Y. Chung, Y. Aghabi, J. Barratt, R. Williams, K. Pritchard-Jones, K. Malik, S. Oltean, K. W. Brown

This study identifies ESRP2 as an epigenetically repressed tumour suppressor in Wilms tumour through DNA hypermethylation, showing its ability to inhibit proliferation and suppress tumour growth.

bioRxiv · Nov 2, 2020Cancer Biology