Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells
D. Huang, J. T. Tran, A. Olson, T. Vollbrecht, M. V. Guryleva, M. Tenuta, R. P. Fuller, T. Schiffner, J. R. Abadejos, L. Couvrette, T. R. Blane, K. Saye, W. Li, E. Landais, A. Gonzalez-Martin, , J. E. Voss
This study shows that engineered HIV bnAb-expressing B cells can be expanded in vivo after vaccination, leading to durable bnAb memory and long-lived plasma cells.
bioRxiv · Mar 17, 2020Immunology