Targeting the Cx43 Carboxyl Terminal H2 Domain Preserves Left Ventricular Function Following Ischemia-Reperfusion Injury
J. Jiang, J. A. Palatinus, H. He, J. Iyyathurai, J. L. Jourdan, D. Hoagland, G. Bultynck, Z. Wang, Z. Zhang, K. Schey, S. Poelzing, F. X. McGowan, R. G. Gourdie
This paper identifies that CT1's interaction with Cx43's carboxyl terminal H2 domain, not ZO-1, mediates its protective effects against ischemia-reperfusion injury in the heart.
bioRxiv · Jun 12, 2019 · PreprintCell Biology