Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells
C. Hansson, C. Lebrero-Fernandez, K. Schön, D. Angeletti, N. Lycke
The paper develops a tolerogenic fusion protein that reduces autoimmune disease symptoms by inducing Tr1 cells and altering cDC1 gene expression via IL-27 signaling.
bioRxiv · Apr 11, 2023Immunology